Simulation of red blood cell motion in microvessels using modified moving particle semi-implicit method

Moving particle semi-implicit; Red blood cell; Micro-capillary. Abstract Red Blood Cells (RBCs) are the main cells in human blood, with a main role in the mechanical properties of blood as a fluid. Several methods have been improved to simulate the mechanical behavior of RBC in micro-capillaries. Since, in microscopic scales, using discrete models is more preferred than continuum methods, the Moving Particle Semi-Implicit method (MPS), which is a recent innovative particle based method, can simulate micro-fluidic flows based on Navier–Stokes equations. Although, by recent developments, the MPS method has turned into a considerable tool for modeling blood flow in micro meter dimensions, some problems, such as a commitment to use small time step sizes, still restrict themethod for largemodels and also for long time simulations. A newmodified semi-implicit algorithm is developed and implemented on RBC motion through microvessels, in order to reduce calculation time by more than a factor of twenty,while the error of position and velocity remains constant. A two-dimensional, parallel plate, fluid flow is simulated based on the proposed method, and the effect of the calculation time decrement is evaluated. Findings indicate a reduction of 90 percent in simulation time compared to previous studies with the same results. This significant developed method could be applied to RBC interaction within micro-capillaries and constricted zones in blood flow. © 2012 Sharif University of Technology. Production and hosting by Elsevier B.V. All rights reserved.